Amplitude-integrated electroencephalography compared with conventional video-electroencephalography for detection of neonatal seizures

Background: Conventional video-electroencephalography (cEEG) is the reference standard for diagnosing and managing neonatal seizures. However, continuous bedside cEEG services are not available in most neonatal units. Hence, an alternative and relatively simple method called amplitude-integrated EEG (aEEG), which uses a limited number of scalp electrodes, has become popular. aEEG allows continuous bedside monitoring of the electrical activity of the brain in neonates.

Citation:
Rakshasbhuvankar AA, Nagarajan L, Zhelev Z, Rao SC. Amplitude-integrated electroencephalography compared with conventional video-electroencephalography for detection of neonatal seizures. Cochrane Database Syst Rev. 2025;8:CD013546.

Keywords:
Electroencephalography; neonates; infant; newborn; randomized controlled trials; seizures; diagnosis; sensitivity and specificity

Abstract:
Background: Conventional video-electroencephalography (cEEG) is the reference standard for diagnosing and managing neonatal seizures. However, continuous bedside cEEG services are not available in most neonatal units. Hence, an alternative and relatively simple method called amplitude-integrated EEG (aEEG), which uses a limited number of scalp electrodes, has become popular. aEEG allows continuous bedside monitoring of the electrical activity of the brain in neonates.