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Resting Energy Expenditure and Metabolic Features in Children With Septo-Optic Dysplasia

Septo-optic dysplasia (SOD) is a major cause of congenital hypopituitarism and is known to be associated with overweight and obesity in up to 44% of children. Given the role of the hypothalamus in hormonal regulation, we sought to assess the association of resting energy expenditure (REE), appetite and physical activity with SOD. 

Citation:
Cullingford DJ, Curran JA, Abraham MB, Siafarikas A, Blackmore AM, Downs J, Choong CSY. Resting Energy Expenditure and Metabolic Features in Children With Septo-Optic Dysplasia. J Endocr Soc. 2025;9(4).

Keywords:
Hyperphagia; hypopituitarism; hypothalamic dysfunction; overweight and obesity; resting energy expenditure; septo-optic dysplasia

Abstract:
Septo-optic dysplasia (SOD) is a major cause of congenital hypopituitarism and is known to be associated with overweight and obesity in up to 44% of children. Given the role of the hypothalamus in hormonal regulation, we sought to assess the association of resting energy expenditure (REE), appetite and physical activity with SOD.