The Vsr-like protein FASTKD4 regulates the stability and polyadenylation of the MT-ND3 mRNA

Expression of the compact mitochondrial genome is regulated by nuclear encoded, mitochondrially localized RNA-binding proteins (RBPs). RBPs regulate the lifecycles of mitochondrial RNAs from transcription to degradation by mediating RNA processing, maturation, stability and translation. The Fas-activated serine/threonine kinase (FASTK) family of RBPs has been shown to regulate and fine-tune discrete aspects of mitochondrial gene expression.

Citation:
Yang X, Stentenbach M, Hughes LA, Siira SJ, Lau K, Hothorn M, Martinou JC, Rackham O, Filipovska A. The Vsr-like protein FASTKD4 regulates the stability and polyadenylation of the MT-ND3 mRNA. Nucleic Acids Res. 2025;53(4).

Keywords:
Mitochondria; genetics; metabolism; proteins; RNA; protein binding

Abstract:
Expression of the compact mitochondrial genome is regulated by nuclear encoded, mitochondrially localized RNA-binding proteins (RBPs). RBPs regulate the lifecycles of mitochondrial RNAs from transcription to degradation by mediating RNA processing, maturation, stability and translation. The Fas-activated serine/threonine kinase (FASTK) family of RBPs has been shown to regulate and fine-tune discrete aspects of mitochondrial gene expression.