Ontogeny of plasma cytokine and chemokine concentrations across the first four months of human life in a Papua new Guinean cohort

Dynamic molecular changes in early life follow a robust ontogeny as the infant immune system adapts to the demands of its new environment. Studies of plasma immunomodulatory cytokines and chemokines have previously demonstrated ontogenetic patterns of immune development across the first week of life. However, how plasma cytokine and chemokines concentrations evolve over the first 4 months of life remains unknown.

Citation:
Nguyen AN, Kouyate TS, Ford R, …….. Ben-Othman R, Kampman B, Kollmann TR, Richmond P, Levy O, van den Biggelaar AHJ, Pomat W, Smolen KK. Ontogeny of plasma cytokine and chemokine concentrations across the first four months of human life in a Papua new Guinean cohort. Cytokine. 2026;197.

Keywords:
Chemokine; Cytokine; Global health; Immune development; Infant; Ontogeny; PNG

Abstract:
Dynamic molecular changes in early life follow a robust ontogeny as the infant immune system adapts to the demands of its new environment. Studies of plasma immunomodulatory cytokines and chemokines have previously demonstrated ontogenetic patterns of immune development across the first week of life. However, how plasma cytokine and chemokines concentrations evolve over the first 4 months of life remains unknown.