Intrauterine growth restriction promotes hypothalamic circadian dysregulation in adult mouse offspring

Adverse prenatal conditions can induce intrauterine growth restriction and increase the risk of adulthood metabolic disease. Mechanisms underlying developmentally programmed metabolic disease remain unclear but may involve disrupted postnatal circadian rhythms and kisspeptin signalling.

Citation:
O’Brien AE, Mark PJ, Smith JT, Wang KCW. Intrauterine growth restriction promotes hypothalamic circadian dysregulation in adult mouse offspring. Journal of Developmental Origins of Health and Disease. 2025;16.

Keywords:
Intrauterine growth restriction; circadian dysregulation; hypothalamus; liver; sex differences

Abstract:
Adverse prenatal conditions can induce intrauterine growth restriction and increase the risk of adulthood metabolic disease. Mechanisms underlying developmentally programmed metabolic disease remain unclear but may involve disrupted postnatal circadian rhythms and kisspeptin signalling.