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Sex-based differences in long-term lipid metabolism, inflammation, and stress regulation after non-severe paediatric burns

Paediatric burn injuries are a global health concern with long-term health consequences, such as psychological, immune, and cardiovascular complications, that can persist even after non-severe injuries. Emerging evidence suggests that biological sex may influence post-burn outcomes in children, as female burn survivors have been shown to experience higher mortality, scarring, anxiety, depression, and poorer quality of life compared to males. 

Citation:
Ryan MJ, Kierath E, Lodge S, Masuda R, Davis JA, D’Vaz N, Barrett LW, Gray N, et al. Sex-based differences in long-term lipid metabolism, inflammation, and stress regulation after non-severe paediatric burns. Burns. 2026;52(6).

Keywords:
Lipidomics; Liquid chromatography-mass spectrometry; ORIGINS; Paediatric Burn injury; Sex differences

Abstract:
Paediatric burn injuries are a global health concern with long-term health consequences, such as psychological, immune, and cardiovascular complications, that can persist even after non-severe injuries. Emerging evidence suggests that biological sex may influence post-burn outcomes in children, as female burn survivors have been shown to experience higher mortality, scarring, anxiety, depression, and poorer quality of life compared to males.