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Advancing CNS tumor diagnostics with expanded DNA methylation-based classification

DNA methylation-based classification is now central to contemporary neuro-oncology, as highlighted by the World Health Organization classification of central nervous system tumors. This expansion is a result of newly identified tumor types discovered through our large online repository and global collaborations, underscoring CNS tumor heterogeneity.

Citation:
Sill M, Schrimpf D, Patel A, Sturm D, …….. Gottardo NG, Haberler C, et al. Advancing CNS tumor diagnostics with expanded DNA methylation-based classification. Cancer Cell. 2026;44(2):340-54.e2.

Keywords:
CNS tumors; DNA methylation; MLOps; artificial intelligence; classification; epigenetics; machine learning; molecular diagnostics; precision medicine; tumor heterogeneity

Abstract:
DNA methylation-based classification is now central to contemporary neuro-oncology, as highlighted by the World Health Organization classification of central nervous system tumors. This expansion is a result of newly identified tumor types discovered through our large online repository and global collaborations, underscoring CNS tumor heterogeneity.