Physicochemical compatibility of alprostadil injection with parenteral medications used in neonatal intensive care settings

The physicochemical compatibility of alprostadil injection with secondary intravenous (IV) drugs and 2-in-1 parenteral nutrition (PN) solutions used in Neonatal Intensive Care Unit settings was investigated.

Citation:
Hamilton AJ, de Silva DTN, Strunk T, Mukadam N, Petrovski M, Batty KT. Physicochemical compatibility of alprostadil injection with parenteral medications used in neonatal intensive care settings. Journal of Pharmaceutical Sciences. 2026;115(1).

Keywords:
Injectables; pediatric; HPLC; physicochemical compatibility;
sorption; alprostadil; Y-site; neonates

Abstract:
The physicochemical compatibility of alprostadil injection with secondary intravenous (IV) drugs and 2-in-1 parenteral nutrition (PN) solutions used in Neonatal Intensive Care Unit settings was investigated.