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CXCR3 is associated with T-cell-induced heart damage in acute rheumatic fever

The pathogenesis of acute rheumatic fever (ARF) is poorly understood, limiting the development of immune-modulating therapies to treat disease and prevent progressive heart damage. Here, participants with definite ARF were compared to other severe acute paediatric conditions and matched healthy controls by profiling circulating immune molecules and cells to inform disease mechanisms and potential druggable pathways.

Citation:
Middleton FM, McGregor R, Lorenz N, ……. Barnett TC, Serralha M, Martin WJ, ……..  Pearson G, Mayo M, …….. Carapetis J, Moreland NJ. CXCR3 is associated with T-cell-induced heart damage in acute rheumatic fever. Nat Commun. 2026;17(1).  

Keywords:
Rheumatic fever; immunology; metabolism; genetics; pathology; T-lymphocytes; interleukin

Abstract:
The pathogenesis of acute rheumatic fever (ARF) is poorly understood, limiting the development of immune-modulating therapies to treat disease and prevent progressive heart damage. Here, participants with definite ARF were compared to other severe acute paediatric conditions and matched healthy controls by profiling circulating immune molecules and cells to inform disease mechanisms and potential druggable pathways.