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Epitope-Binding Characteristics for Risk versus Protective DRB1 Alleles for Visceral LeishmaniasisOur data provide insight into the molecular mechanisms underpinning the association of HLA-DRB1 alleles with risk versus protection in visceral leishmaniasis in humans
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Common and Rare Genetic Variants That Could Contribute to Severe Otitis Media in an Australian Aboriginal PopulationOur goal was to identify genetic risk factors for severe otitis media (OM) in Aboriginal Australians.
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Burkholderia pseudomallei evades Nramp1 (Slc11a1)- and NADPH oxidase-mediated killing in macrophages and exhibits Nramp1-dependent virulence gene expressionHere we show that transfected macrophages stably expressing wild-type Nramp1 (Nramp1+) control the net replication of B. thailandensis, but not B. pseudomallei.
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Transcription start site profiling of 15 anatomical regions of the Macaca mulatta central nervous systemWe believe this data represents a useful resource to understand the central nervous system in macaque.
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A "Candidate-Interactome" Aggregate Analysis of Genome-Wide Association Data in Multiple SclerosisThe interaction between genotype and Epstein Barr virus emerges as relevant for multiple sclerosis etiology.
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Epigenetics in infectious diseasesViruses, bacteria, and parasites have developed strategies to invade and establish long-term infections in their hosts.
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Alternative Recruitment Strategies Influence Saliva Sample Return Rates in Community-Based Genetic Association StudiesUsing data from three large-scale genetic association studies we compared recruitment strategy and sample return rates.
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Insights into the possible role of IFNG and IFNGR1 in Kala-azar and Post Kala-azar Dermal Leishmaniasis in Sudanese patientsUniformly low expression of IFN and IFNGR1 in PKDL skin biopsies could explain parasite persistence
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Wound healing genes and susceptibility to cutaneous leishmaniasis in BrazilHere we examined single nucleotide polymorphisms (SNPs) in these genes as risk factors for cutaneous (CL) and mucosal leishmaniasis (ML), and leishmaniasis...
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CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based studyTo look at the interplay between PMN and macrophages in disease progression in humans we asked whether polymorphisms at genes that regulate their infiltration..