Search
Research
Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infectionPoor maternal diet during pregnancy is a risk factor for severe lower respiratory infections in the offspring, but the underlying mechanisms remain elusive. Here, we demonstrate that in mice a maternal low-fiber diet led to enhanced LRI severity in infants because of delayed plasmacytoid dendritic cell recruitment and perturbation of regulatory T cell expansion in the lungs.
Research
Copy number variation in tRNA isodecoder genes impairs mammalian development and balanced translationThe number of tRNA isodecoders has increased dramatically in mammals, but the specific molecular and physiological reasons for this expansion remain elusive. To address this fundamental question we used CRISPR editing to knockout the seven-membered phenylalanine tRNA gene family in mice, both individually and combinatorially.
Research
The relationship between personality traits and psychotic like experiences in a large non-clinical adolescent sampleOur findings suggest that the chance of having psychotic like experiences is more likely for adolescents with certain personality traits.
Research
The AEDI: From Research to PolicyHere we summarise some recent research using the AEDI data and show how the Fraser Mustard Centre is using such research to help inform policy-makers.
Research
Parental experiences of early pulmonary surveillance for children with cystic fibrosis: A research proposal for improved family psychosocial outcomesThe proposed study intends to explore parental experiences, including coping, related to their child's involvement in the early surveillance program.
Research
Effectiveness and experiences of families participating in peer led parenting support programsWhat is the effectiveness and experience of families participating in peer led parenting support programs delivered as home visiting programs?
Research
Relationship between family quality of life and day occupations of young people with Down syndromeThis study aimed to explore relationships between family quality of life, day occupations and activities of daily living of young persons with Down syndrome.
Research
Micronutrient intakes from food and supplements in Australian adolescentsWe assessed micronutrient intakes in adolescents to determine whether supplement use optimises intakes.
Research
Oral contraceptive use in girls and alcohol consumption in boys are associated with increased blood pressure in late adolescenceWe aimed to assess the association of health behaviours with BP in adolescents, using data from the Western Australian Pregnancy (Raine) Study.
Research
The Neuroprotective Efficacy of Cell-Penetrating Peptides TAT, Penetratin, Arg-9, and Pep-1 in Glutamic Acid, Kainic Acid, and In Vitro Ischemia Injury ModelsCell-penetrating peptides (CPPs) are small peptides (typically 5-25 amino acids), which are used to facilitate the delivery of normally non-permeable...