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Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma controlThe hallmark of atopic asthma is transient airways hyperresponsiveness (AHR) preceded by aeroallergen-induced Th-cell activation.
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Evaluation of impact of 23 valent pneumococcal polysaccharide vaccine following 7 valent pneumococcal conjugate vaccine in Australian Indigenous children.Background: High incidence and serotype diversity of invasive pneumococcal disease (IPD) in Indigenous children in remote Australia led to rapid introduction of
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Th2-associated immunity to bacteria in asthma in teenagers and susceptibility to asthmaBacterial colonisation of the airways is associated with increased risk of childhood asthma
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Infection and the development of allergic diseaseAn improved understanding of the roles of protein kinases in intracellular signalling and disease progression has driven significant advances in protein...
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Interactions between innate and adaptive immunity in asthma pathogenesis: new perspectives from studies on acute exacerbationsAtopic asthma, which is at its highest prevalence during childhood/young adulthood, represents the main focus of this review.
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Cord-blood respiratory syncytial virus antibodies and respiratory health in first 5 years of lifeTo determine the potential longer-term effects of maternal antenatal respiratory syncytial virus (RSV) vaccination, we examined the association between cord-blood RSV-neutralizing antibodies (RSV-NA) and RSV infections in the first 2 years of life, RSV-NA at 3 years, and respiratory health to age 5 years.
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An exposome perspective: Early-life events and immune development in a changing worldHere we review the historical origins of exposome research and define a new concept, the metaexposome
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Distinguishing benign from pathologic TH2 immunity in atopic childrenIn addition to its role in blocking TH2 effector activation in the late-phase allergic response, IL-10 is a known IgG1 switch factor
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Environmental Factors in Children's Asthma and Respiratory EffectsAsthma is more common in childhood than in adulthood and is more correctly thought of as a syndrome than as a discrete condition.