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There is growing evidence that lung function in early-life predicts later lung function. Adverse events over the lifespan might influence an individual’s lung function trajectory, resulting in poor respiratory health. The aim of this study is to identify early-life risk factors and their impact on lung function trajectories to prevent long-term lung impairments.
The airway epithelium of children with wheeze is characterized by defective repair that contributes to disease pathobiology. Dysregulation of developmental processes controlled by Notch has been identified in chronic asthma. However, its role in airway epithelial cells of young children with wheeze, particularly during repair, is yet to be determined.
Acute wheezing is one of the most common hospital presentations for young children. Respiratory syncytial virus (RSV) and rhinovirus (RV) species A, B and the more recently described species C are implicated in the majority of these presentations. However, the relative importance and age-specificities of these viruses have not been defined.
Asthma is a chronic inflammatory disease of the small and large conducting airway mucosa characterised by Th2 cell immunity.
Atopy and asthma are commonly initiated during early life, and there is increasing interest in the development of preventive treatments for at-risk children.
This study investigates the impact of measuring adherence and providing feedback on medication usage by children with unstable asthma.
This study aimed to investigate the effects of different macro-environments on asthma genotype-phenotype associations in 2 geographically separated populations
Anti-viral innate immune responses may be impaired in asthma, although the mechanisms are not well understood.
One of the major challenges in health studies with a spatial dimension is to produce valid and meaningful geographical representations of risk.
The aims of this study were to investigate kinin receptor expression on eosinophils of asthmatic and healthy subjects