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Prevention of Allergy/Asthma - New StrategiesThis review focuses on the scientific rationale for early intervention aimed at asthma prophylaxis and discusses therapeutic approaches
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Developments in the field of allergy in 2014 through the eyes of Clinical and Experimental AllergyThe pathogenesis of asthma continues to be a major topic of interest to our authors with reviews and original papers on the role of viruses, mechanisms of...
Research
ACE2 expression is elevated in airway epithelial cells from older and male healthy individuals but reduced in asthmaCOVID-19 is complicated by acute lung injury, and death in some individuals. It is caused by SARS-CoV-2 that requires the ACE2 receptor and serine proteases to enter AEC. We determined what factors are associated with ACE2 expression particularly in patients with asthma and COPD. We obtained lower AEC from 145 people from two independent cohorts, aged 2-89 years, Newcastle (n = 115) and Perth (n = 30), Australia. The Newcastle cohort was enriched with people with asthma (n = 37) and COPD (n = 38). Gene expression for ACE2 and other genes potentially associated with SARS-CoV-2 cell entry was assessed by qPCR, and protein expression was confirmed with immunohistochemistry on endobronchial biopsies and cultured AEC.
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Identifying pediatric lung disease: A comparison of forced oscillation technique outcomesThese findings suggest the utility of specific FOT outcomes is dependent on the respiratory disease being assessed
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In utero cigarette smoke exposure impairs somatic and lung growth in BALB/c miceThe aim of this study was to assess whether in utero tobacco smoke exposure alone affects early-life lung growth and development. Pregnant BALB/c mice...
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Asthma steroid without side effectsWestern Australia has joined a major international study that could significantly change the treatment of asthma in children.
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Lung problems continue into childhood for premmie babiesNew research from Perth’s The Kids Research Institute Australia shows that babies born premature continue to have lung problems well into childhood.
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Vitamin D deficiency linked to childhood asthmaResearchers at The Kids Research Institute Australia have found children with vitamin D deficiency are more likely to develop asthma.
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Video: Asthma, how serious is it?Australia has one of the highest burdens of asthma in the world. In this video, two Perth families share their story of raising children with the respiratory co
Research
Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma controlThe hallmark of atopic asthma is transient airways hyperresponsiveness (AHR) preceded by aeroallergen-induced Th-cell activation.