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Research

Identification of epithelial phospholipase A2 receptor 1 as a potential target in asthma

PLA2R1 is increased in the airway epithelium in asthma, and serves as a regulator of airway hyperresponsiveness, airway permeability, antigen sensitization, and airway inflammation

Research

Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responses

Differential network analysis of allergen-induced CD4 T cell responses can unmask covert disease-associated genes and pin point novel therapeutic targets

Research

Respiratory infection- and asthma-prone, low vaccine responder children demonstrate distinct mononuclear cell DNA methylation pathways

nfants with frequent viral and bacterial respiratory infections exhibit compromised immunity to routine immunizations. They are also more likely to develop chronic respiratory diseases in later childhood. This study investigated the feasibility of epigenetic profiling to reveal endotype-specific molecular pathways with potential for early identification and immuno-modulation. 

Research

Comparison of rhinovirus antibody titers in children with asthma exacerbations and species-specific rhinovirus infection

Asthma exacerbations are associated with human rhinovirus (HRV) infections, and more severe exacerbations are associated with HRV-C.

Research

Respiratory allergen from house dust mite is present in human milk and primes for allergic sensitization in a mouse model of asthma

These data highlight that antigen administration to the neonate through the oral route may contribute to child allergic sensitization and have important...

News & Events

Asthma steroid without side effects

Western Australia has joined a major international study that could significantly change the treatment of asthma in children.

News & Events

Vitamin D deficiency linked to childhood asthma

Researchers at The Kids Research Institute Australia have found children with vitamin D deficiency are more likely to develop asthma.

News & Events

Video: Asthma, how serious is it?

Australia has one of the highest burdens of asthma in the world. In this video, two Perth families share their story of raising children with the respiratory co

News & Events

State Government boost for The Kids research

The Kids Research Institute Australia researchers have been awarded five of eight State Government awards designed to help cover the hidden costs of conducting research.

News & Events

Lung problems continue into childhood for premmie babies

New research from Perth’s The Kids Research Institute Australia shows that babies born premature continue to have lung problems well into childhood.