Search
Research
Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infectionGroup A Streptococcus (GAS) is a Gram-positive bacterial pathogen that causes an array of infectious diseases in humans. Accumulating clinical evidence suggests that proinflammatory interleukin (IL)-1beta signaling plays an important role in GAS disease progression.
Research
Rheumatic heart disease in Timor-Leste school students: an echocardiography-based prevalence studyThe rates of RHD in Timor-Leste are among the highest in the world, and prevalence is higher among girls than boys
Research
Calculation of the age of the first infection for skin sores and scabies in five remote communities in northern AustraliaThe young age of the first infection with skin sores and scabies reflects the high disease burden in these communities
Research
Rheumatic Heart Disease Severity, Progression and Outcomes: A Multi‐State ModelThe prognosis of young Indigenous Australians diagnosed with severe RHD is bleak; interventions must focus on earlier detection and treatment
Research
Echocardiographic screening for rheumatic heart disease in indigenous Australian children: A cost-utility analysisEchocardiographic screening for rheumatic heart disease is cost-effective in our context
Research
Burden of cardiovascular diseases in the Eastern Mediterranean Region, 1990-2015: findings from the Global Burden of Disease 2015 studyThe age-standardized disability-adjusted life years rates in the Eastern Mediterranean Region are considerably higher than the global average
Research
Disparity in Mortality From Rheumatic Heart Disease in Indigenous AustraliansThis study was undertaken to provide a comprehensive examination of rheumatic heart disease mortality rates and trends in Indigenous Australians.
Research
Treating trade: the case for clinical engagement with regional trade agreementsThe global burden of non-communicable diseases (NCDs) continues to grow. Although developing settings face fastest growth in incidence, no country is exempt.
Research
Towards Improving Point-of-Care Diagnosis of Non-malaria Febrile Illness: A Metabolomics ApproachThis study demonstrates the potential use of plasma metabolites to identify causality in children with severe febrile illness in malaria-endemic settings
Research
Development of Group A streptococcal vaccines: an unmet global health needThis review provides an update on the current status of Group A Streptococcus vaccine development, & describes global efforts to accelerate the development...