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The Group A β-hemolytic Streptococcus pharyngeal carriage rates seen in Uganda (15.9%) are higher than the most recent pooled results globally, at 12%

Health service utilisation in this setting may be enhanced by improving general awareness of the significance of childhood skin infections

There is low coverage of the multivalent M protein vaccine in our setting, emphasizing the need to reformulate the vaccine to improve coverage

Skin infection burden in remote Aboriginal communities can be reduced by the See, Treat, Prevent (SToP skin sores and scabies) trial

We write this perspective to raise awareness of antimicrobial resistance as an issue in Indigenous primary health care

Health care-associated bacteraemia has a significant impact on child health, exceeding the number of community-acquired bacteraemia at our hospital

Skin infections are an under-appreciated and dominant reason for presentation to primary healthcare centres in these indigenous communities

Implementation of molecular testing could improve antibiotic use in this high-burden setting

We overview the changing epidemiology of Group A Streptococcus infections and the genetic alterations that accompany the emergence of Group A Streptococcus strains

A summary of the literature regarding the use of adjunctive protein synthesis inhibitors for toxin suppression in the setting of S. aureus infections is presented