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Stiffness Mediated-Mechanosensation of Airway Smooth Muscle Cells on Linear Stiffness Gradient HydrogelsIn obstructive airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), the extracellular matrix (ECM) protein amount and composition of the airway smooth muscle (ASM) is often remodelled, likely altering tissue stiffness. The underlying mechanism of how human ASM cell (hASMC) mechanosenses the aberrant microenvironment is not well understood.
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Bullying and psychosocial adjustment among children with and without asthmaChildren with asthma face serious mental health risk, but the pathways remain unclear. This study aimed to examine bullying victimisation and perpetration in children with asthma and a comparison sample without a chronic health condition, and the role of bullying in moderating psychosocial adjustment outcomes for those with asthma. A sample of children with and without asthma, and their parents, were recruited from hospital clinics.
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OMIP 076: High-dimensional immunophenotyping of murine T-cell, B-cell, and antibody secreting cell subsetsThere is now considerable evidence demonstrating that both prenatal and postnatal exposure to particular classes of microbial stimuli can provide beneficial signals during early life immune development, resulting in the protection against future inflammatory disease.
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Fragranced consumer products: effects on asthmatic AustraliansMost asthmatics would prefer workplaces, healthcare facilities, and environments that are fragrance-free, which could help reduce adverse effects
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Global allergy forum and second davos declaration 2013 allergy: Barriers to cure - Challenges and actions to be takenThe epidemic increase in the prevalence of allergic disease, which first started in the industrialized countries in the 1960s, may have reached a peak in the...
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The safety and feasibility of the inhaled mannitol challenge test in young childrenMannitol challenge tests are used clinically to diagnose asthma and, in particular, exercise-induced broncoconstriction (EIB) in adults and children above 6...
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Vitamin D deficiency and the lung: Disease initiator or disease modifier?Vitamin D deficiency is a global public health problem and has been associated with an increased incidence and severity of many diseases including diseases...
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DNA Methylation Profiles of Airway Epithelial Cells and PBMCs from Healthy, Atopic and Asthmatic ChildrenAllergic inflammation is commonly observed in a number of conditions that are associated with atopy including asthma, eczema and rhinitis.
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Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheezeThe aim of this study was to explore associations between severe respiratory infections and atopy in early childhood with persisting wheeze and asthma.
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Defective function at the epithelial junction: A novel therapeutic frontier in asthma?The airway epithelium forms a highly regulated physical barrier that normally prevents invasion of inhaled pathogens and allergens from the airway lumen.