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Air pollution exposure has increased in recent years and there is evidence that exposure to particulate matter can lead to adverse respiratory outcomes.

In this review, we consider recent evidence regarding hypoxia and sterile inflammation in cystic fibrosis airways

The prevalence of LDCT-detected indeterminate lung nodules in 906 individuals with significant asbestos exposure was 8.5%, lower than many other CT studies

Evidence into the role of TGF-β1 in airway epithelial repair in asthma is still controversial. This study tested the hypothesis that the reduced TGF-β1 levels previously observed in paediatric asthmatic airway epithelial cells directly contribute to the dysregulated repair seen in these cells.

Free NE activity is deleterious for epithelial homeostasis and support the hypothesis that proteases in the airway contribute to CF structural lung disease

The present study investigated whether lung function measured by forced oscillation technique would be impaired in the presence of infection,...

There is no consensus about which outcomes should be evaluated in studies of pulmonary exacerbations in people with cystic fibrosis (CF). Outcomes used for evaluation should be meaningful; that is, they should capture how people feel, function or survive and be acknowledged as important to people with CF, or should be reliable surrogates of those outcomes. We aimed to summarise the outcomes and corresponding endpoints which have been reported in studies of pulmonary exacerbations, and to identify those which are most likely to be meaningful.

RHINO researchers from The Kids' Wal-yan Respiratory Research Centre, will analyse ORIGINS data and turn it into meaningful respiratory and allergy outcome data that can be used by researchers around the world.