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Experiences Impacting the Quality of Life of Mothers of Children With Autism and Intellectual DisabilityMothers of autistic children and adults bewtween 11 and 24 years old were interviewed about the impacts and rewards associated with their children's disability.
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CRISPR-Cas9-generated PTCHD1 2489T>G stem cells recapitulate patient phenotype when undergoing neural inductionAn estimated 3.5%-5.9% of the global population live with rare diseases, and approximately 80% of these diseases have a genetic cause. Rare genetic diseases are difficult to diagnose, with some affected individuals experiencing diagnostic delays of 5-30 years. Next-generation sequencing has improved clinical diagnostic rates to 33%-48%. In a majority of cases, novel variants potentially causing the disease are discovered.
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The first six months of life: A systematic review of early markers associated with later autismThere is now good evidence that behavioural signs of autism spectrum conditions (autism) emerge over the first two years of life. Identifying clear developmental differences early in life may facilitate earlier identification and intervention that can promote longer-term quality of life. Here we present a systematic review of studies investigating behavioural markers of later autism diagnosis or symptomology taken at 0-6 months.
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The association between autism and schizophrenia spectrum disorders: A review of eight alternate models of co-occurrenceUnderstanding how and why these disorders co-occur has important implications for diagnosis, treatment, and prognosis, as well as for developing fundamental...
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Perceived gender ratings for high and low scorers on the autism-spectrum quotient consistent with the extreme male brain account of autismThis study tested the 'Extreme Male Brain' theory & androgyny accounts of Autism spectrum disorder.
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Maternal Psychiatric Disorder and the Risk of Autism Spectrum Disorder or Intellectual Disability in Subsequent OffspringThis study adds to existing evidence that the rate of pre-existing psychiatric disorders in mothers of children with autism spectrum disorder is higher than...
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Short report: Relationship between restricted and repetitive behaviours in children with autism spectrum disorder and their parentsRestricted and repetitive behaviours constitute a core symptom domain of autism spectrum disorder
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MACROD2 gene associated with autistic-like traits in a general population sampleThe MACROD2 gene is a strong positional candidate risk factor for autistic-like traits in the general population
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Prenatal maternal stress associated with ADHD and autistic traits in early childhoodResearch suggests that offspring of mothers who experience high levels of stress during pregnancy are more likely to have problems in neurobehavioral...
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Cell phone use by adolescents with Asperger SyndromeWhile young people have generally been at the forefront of the adoption and use of new communications technologies, little is known of uses by exceptional youth