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Research
The potential of antisense oligonucleotide therapies for inherited childhood lung diseasesAntisense oligonucleotides are an emerging therapeutic option to treat diseases with known genetic origin. In the age of personalised medicines, antisense oligonucleotides can sometimes be designed to target and bypass or overcome a patient's genetic mutation, in particular those lesions that compromise normal pre-mRNA processing. Antisense oligonucleotides can alter gene expression through a variety of mechanisms as determined by the chemistry and antisense oligomer design.
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T-cell responses against rhinovirus species A and C in asthmatic and healthy childrenInfections by RV species A and C are the most common causes of exacerbations of asthma and a major cause of exacerbations of other respiratory disease.
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Adolescents' Perspectives on a Mobile App for Relationships: Cross-Sectional SurveyAdolescents were likely to use a mobile phone app for relationship support, and use was not influenced by background characteristics
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Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysisWe think that variants in genes involved in fructose metabolism and ChREBP-FGF21 pathway interacts with SSB intake to exacerbate associations with SSB intake.
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Identification of health risk behaviours among adolescent refugees resettling in Western AustraliaWe aim to identify health risk behaviours among adolescent refugees resettling in WA and assess the feasibility of using a standardised questionnaire.
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Assessing motor skills to inform a fetal alcohol spectrum disorder diagnosis focusing on persons older than 12 years: a systematic review of the literatureA systematic review of current evidence using various electronic databases was conducted. Studies were appraised using a recognised clinical appraisal tool.
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Safety and immunogenicity of pneumococcal conjugate vaccines in a high-risk population: a randomised controlled trial of PCV in Papua New Guinean infantsInfant vaccination with 3 doses of PCV10 or PCV13 is safe and immunogenic in a highly endemic setting
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Caregiver’s attitudes, beliefs, and experiences for influenza vaccination in Australian children with medical comorbiditiesInfluenza vaccination recommendation by children’s hospital physicians and previous vaccine receipt in hospital was associated with vaccine uptake
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High burden of infectious disease and antibiotic use in early life in Australian Aboriginal communitiesEarly life infections drive high antibiotic prescribing rates in remote Aboriginal communities
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A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastomaWe present a curated panel of 12 readily-usable, cell lines representing the spectrum of molecular subtypes of IDH-wildtype glioblastoma