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Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastomaMedulloblastoma (MB) consists of four core molecular subgroups with distinct clinical features and prognoses. Treatment consists of surgery, followed by radiotherapy and cytotoxic chemotherapy. Despite this intensive approach, outcome remains dismal for patients with certain subtypes of MB, namely, MYC-amplified Group 3 and TP53-mutated SHH. Using high-throughput assays, six human MB cell lines were screened against a library of 3208 unique compounds. We identified 45 effective compounds from the screen and found that cell cycle checkpoint kinase (CHK1/2) inhibition synergistically enhanced the cytotoxic activity of clinically used chemotherapeutics cyclophosphamide, cisplatin, and gemcitabine.
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Topical treatment of vulvodynia, dyspareunia and pudendal neuralgia: A single clinic audit of amitriptyline and oestriol in organogelVulvodynia and pudendal neuralgia comprise significant contributors to vulvar-related pain and its impact on daily life. A retrospective clinical audit was conducted at the Women's Health & Research Institute of Australia, Sydney, to determine the pattern of use and the efficacy of the application of topical amitriptyline 0.5% plus oestriol 0.03% in organogel (AOO), to the vulvar vestibule in reducing the impact of pain on daily life.
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Maternal antibiotic exposure during pregnancy and hospitalization with infection in offspring: a population-based cohort studyAntibiotic exposure before or during pregnancy was associated with increased risk of childhood hospitalized infections
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Mesothelioma in australia: A reviewA multidisciplinary approach to caring for patients with malignant mesothelioma and their carers is vital.
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Record linkage study of the pathogen-specific burden of respiratory viruses in childrenReliance on hospital discharge diagnosis codes alone will likely underestimate the burden of respiratory viruses
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Reproducibility of the plasma glucose response to moderate-intensity exercise in adolescents with Type 1 diabetesThe plasma glucose response to moderate-intensity exercise can be reproducible in adolescents with Type 1 diabetes
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Characterizing the risk of respiratory syncytial virus in infants with older siblings: a population-based birth cohort studyOur results lend support to a vaccination strategy which includes family members in order to provide maximum protection for newborn babies.
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Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific mannerMaintaining sufficient vitamin D is necessary for optimal lung health, and vitamin D may modulate the lung microbiome in a sex-specific fashion
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Asbestos-Related Non-Malignant Pleural Disease and MesotheliomaThis chapter deals with asbestos-related non-malignant pleural disease and mesothelioma.
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A longitudinal study of natural antibody development to pneumococcal surface protein A families 1 and 2 in Papua New Guinean Highland children: a cohort studyPneumococcal surface protein A is immunogenic and natural anti-PspA immune responses are acquired through exposure and develop with age