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Research
Simultaneous Targeting of DNA Replication and Homologous Recombination in Glioblastoma with a Polyether IonophoreOur findings highlight the potential of salinomycin to induce DNA lesions and inhibit homologous recombination to greatly enhance the effect of radiotherapy
Research
Diverse Anti-Tumor Immune Potential Driven by Individual IFNα SubtypesOur data shows that the expression of distinct IFNα subtypes within the tumor microenvironment results in different anti-tumor activities
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Primary central nervous system lymphoma: Initial features, outcome, and late effects in 75 children and adolescentsChildren with Primary Central Nervous System Lymphoma and no immunodeficiency have a good outcome
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Parental smoking, maternal alcohol consumption during pregnancy and the risk of neuroblastoma in children. A pooled analysis of the ESCALE and ESTELLE French studiesOur findings provide some evidence of an association between maternal smoking during pregnancy and Neuroblastoma
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Activation of ERBB4 in Glioblastoma Can Contribute to Increased Tumorigenicity and Influence Therapeutic ResponseThe functional effects of increased ERBB4 activation identify ERBB4 as a potential prognostic and therapeutic target
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Most clinical anti-EGFR antibodies do not neutralize both wtEGFR and EGFRvIII activation in gliomaWe discovered a previously unknown major resistance mechanism in glioma in that most EGFR domain III-targeting antibodies do not neutralize EGFRvIII
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International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine gliomaThis multi-center study provides valuable information on the success rate of establishing patient-derived pre-clinical models of diffuse intrinsic pontine glioma
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Exercise training improves vascular function and secondary health measures in survivors of pediatric oncology related cerebral insultThis study demonstrates that exercise is achievable and has positive effects on vascular function, submaximal fitness, local strength and physical activity in a population of AYA survivors of pediatric oncology related cerebral insult
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New therapeutic opportunities from dissecting the pre-B leukemia bone marrow microenvironmentWe provide evidence that targeting leukemia-induced bone loss is a therapeutic strategy for pre-B ALL
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PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding proteinA novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis
News & Events
Meat mattersType 1 diabetes patients require about 50 per cent more insulin with a high protein meal then with a low protein meal to maintain a stable blood glucose level, according to new research from the Children’s Diabetes Centre at The Kids Research Institute Australia.
News & Events
ENDIA in the newsMOSMAN Park family-of-five is part of a study aiming to determine the factors that trigger, protect or develop type 1diabetes in young children.
News & Events
Diabetes service celebrates 50th yearIt’s hard to believe that 20 years has passed since April Welsh, 5, was pictured with Professor Tim Jones in a story about type 1 diabetes research. Plenty has changed but one constant remains — Professor Jones still works for WA’s only paediatric diabetes service which celebrates its 50th year.