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Linking lung function and inflammatory responses in ventilator-induced lung injuryDespite decades of research, the mechanisms of ventilator-induced lung injury are poorly understood...
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Genome-wide association and large-scale follow up identifies 16 new loci influencing lung functionPulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease.
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Role of innate immunity in the development of allergy and asthmaThe purpose of this review is to examine the role of innate immunity in the lungs in the development of allergy and asthma.
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Global strategy for the diagnosis and management of asthma in children 5 years and youngerAsthma is the most common chronic disease of childhood and the leading cause of childhood morbidity from chronic disease as measured by school absences...
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Neonatal immune function and inflammatory illnesses in later life: lessons to be learnt from the developing world?With the emergence of allergic and autoimmune diseases in populations that have started to transit to a western lifestyle, there has been an increasing...
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The hygiene hypothesis revisited: role of materno-fetal interactionsFor 20 years, the hygiene hypothesis has dominated attempts to explain the increasing prevalence of allergic disease. A causal link between maternal innate immu
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The role of GSTP1 polymorphisms and tobacco smoke exposure in children with acute asthmaThe glutathione S-transferase enzymes (GSTs) play an important role in the detoxification of environmental tobacco smoke (ETS), which contributes to airway infl
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House dust mite allergens in asthma and allergyIgE antibodies in house dust mite (HDM) allergy follow a predictable pattern. Half are directed against two dominant allergens and the remainder largely against
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1,25-dihydroxyvitamin D3 enhances the ability of transferred CD4+ CD25+ cells to modulate T helper type 2-driven asthmatic responsesThe severity of allergic diseases may be modified by vitamin D. However, the immune pathways modulated by the active form of vitamin D, 1,25-dihydroxyvitamin D.
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UV inhibits allergic airways disease in mice by reducing effector CD4 T cellsIn human asthma, and experimental allergic airways disease in mice, antigen-presenting cells and CD4(+) effector cells at the airway mucosa orchestrate, and CD4