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Transcriptional rewiring in CD8+ T cells: implications for CAR-T cell therapy against solid tumoursT cells engineered to express chimeric-antigen receptors (CAR-T cells) can effectively control relapsed and refractory haematological malignancies in the clinic. However, the successes of CAR-T cell therapy have not been recapitulated in solid tumours due to a range of barriers such as immunosuppression, poor infiltration, and tumour heterogeneity.
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IDH-mutant gliomas in children and adolescents - from biology to clinical trialsGliomas account for nearly 30% of all primary central nervous system (CNS) tumors in children and adolescents and young adults (AYA), contributing to significant morbidity and mortality. The updated molecular classification of gliomas defines molecularly diverse subtypes with a spectrum of tumors associated with age-distinct incidence.
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Most clinical anti-EGFR antibodies do not neutralize both wtEGFR and EGFRvIII activation in gliomaWe discovered a previously unknown major resistance mechanism in glioma in that most EGFR domain III-targeting antibodies do not neutralize EGFRvIII
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Simultaneous Targeting of DNA Replication and Homologous Recombination in Glioblastoma with a Polyether IonophoreOur findings highlight the potential of salinomycin to induce DNA lesions and inhibit homologous recombination to greatly enhance the effect of radiotherapy
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Optimized peripheral blood progenitor cell mobilization for autologous hematopoietic cell transplantation in children with high-risk and refractory malignanciesOur approach to hematopoietic progenitor cells mobilization resulted in highly effective HPC harvest in children and adolescents with high-risk cancers
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Fetal growth and childhood acute lymphoblastic leukemia: Findings from the childhood leukemia international consortiumThe evidence that accelerated fetal growth is associated with a modest increased risk of childhood ALL is strong and consistent with known biological...
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Parental occupational exposure to engine exhausts and childhood brain tumorsIncreased risks were observed for maternal exposure to diesel exhaust any time before the child's birth and paternal exposure around the time of the child's...
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Cancer Survival and Excess Mortality Estimates among Adolescents and Young Adults in Western Australia, 1982-2004: A Population-Based StudyA cancer diagnosis in adolescents and young adults conferred substantial survival decrement.
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Parental occupational exposure to engine exhausts and childhood brain tumorsParental occupational exposure to engine exhausts and childhood brain tumors.
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Parental occupational exposure to exhausts, solvents, glues and paints, and risk of childhood leukemiaIt is unknown whether parental occupational exposure to chemicals before during and after pregnancy increases the risk of acute lymphoblastic...