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Prevalence of chronic wet cough and protracted bacterial bronchitis in aboriginal childrenStrategies to address reasons for and treatment of chronic wet cough and protracted bacterial bronchitis in young Aboriginal children in remote north Western Australia are required
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Spaceship earth revisited: The co‐benefits of overcoming biological extinction of experience at the level of person, place and planetThis commentary focuses the ways in which microbes, as an essential part of all ecosystems, provide a vital link between personal and planetary systems
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Hearing aid review appointment: clients’ reasons for attendance and non-attendanceAppointment attendance is influenced by some factors modifiable by the clinician, including providing better education
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Panel 8: Vaccines and immunologyReview and highlight of the significant advances made towards vaccine development and understanding of the immunology of otitis media
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The effect of upgrades to childcare outdoor spaces on preschoolers’ physical activity: Findings from a natural experimentThis natural experiment investigated the influence of early childhood education and care outdoor physical environment upgrade on preschoolers' physical activity
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Advances in Exercise, Physical Activity, and DiabetesWe screened more than 750 potentially eligible titles on PubMed and other common search engines for manuscripts on “exercise and diabetes”
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Misgendering and experiences of stigma within health care settings for transgender individualsMisgendering within the health care system can significantly affect the mental and physical health of transgender individuals
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Preclinical Evaluation of Carfilzomib for Infant KMT2A-Rearranged Acute Lymphoblastic LeukemiaInfants with KMT2A-rearranged B-cell precursor acute lymphoblastic leukemia (ALL) have poor outcomes. There is an urgent need to identify novel agents to improve survival. Proteasome inhibition has emerged as a promising therapeutic strategy for several hematological malignancies. The aim of this study was to determine the preclinical efficacy of the selective proteasome inhibitor carfilzomib, for infants with KMT2A-rearranged ALL.
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A flexible computational pipeline for research analyses of unsolved clinical exome casesExome sequencing has enabled molecular diagnoses for rare disease patients but often with initial diagnostic rates of ~25-30%. Here we develop a robust computational pipeline to rank variants for reassessment of unsolved rare disease patients. A comprehensive web-based patient report is generated in which all deleterious variants can be filtered by gene, variant characteristics, OMIM disease and Phenolyzer scores, and all are annotated with an ACMG classification and links to ClinVar.
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Case Report: Neonatal Varicella Acquired From Maternal ZosterThe incidence of neonatal varicella has decreased dramatically since the introduction of the varicella vaccination. Although the varicella zoster virus is often associated with a mild infection, it may cause severe morbidity and mortality, particularly in the neonatal period and immunocompromised hosts. We report a case of neonatal varicella acquired from maternal zoster in a mother on biological immunosuppressive therapy.