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Personal network inference unveils heterogeneous immune response patterns to viral infection in children with acute wheezingHuman rhinovirus (RV)-induced exacerbations of asthma and wheeze are a major cause of emergency room presentations and hospital admissions among children. Previous studies have shown that immune response patterns during these exacerbations are heterogeneous and are characterized by the presence or absence of robust interferon responses.
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Mapping the landscape of chromatin dynamics during naïve CD4+ T-cell activationT-cell activation induces context-specific gene expression programs that promote energy generation and biosynthesis, progression through the cell cycle and ultimately cell differentiation. The aim of this study was to apply the omni ATAC-seq method to characterize the landscape of chromatin changes induced by T-cell activation in mature naïve CD4+ T-cells.
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Respiratory viral infections and host responses; insights from genomicsReview of the viral sensing pathways and organizing principles that govern the innate immune response to infection
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A genomics-based approach to assessment of vaccine safety and immunogenicity in childrenThis methodology has significant potential to identify covert interactions between inflammatory pathways triggered by vaccination, and as such may be a...
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Immunoinflammatory responses to febrile lower respiratory infections in infants display uniquely complex/intense transcriptomic profilesthe association between infant LRTI and risk for persistent wheeze/asthma in this cohort is generally stronger for fLRTIs than for other infection categories
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Rapid recruitment of CD14+ monocytes in experimentally induced allergic rhinitis in human subjectsMononuclear phagocyte population is directly involved in the production of proinflammatory chemokines that attract other immune cells
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Breastfeeding and Neonatal Age Influence Neutrophil-Driven Ontogeny of Blood Cell Populations in the First Week of Human LifeThe first few days of life are characterized by rapid external and internal changes that require substantial immune system adaptations. Despite growing evidence of the impact of this period on lifelong immune health, this period remains largely uncharted.
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Bilateral murine tumor models for characterizing the response to immune checkpoint blockadeThis protocol describes bilateral murine tumor models that display a symmetrical yet dichotomous response to immune checkpoint blockade
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Interferon regulatory factor 7 is a major hub connecting interferon-mediated responses in virus-induced asthma exacerbations in vivoThe objective of this study was to elucidate the molecular networks that underpin virus-induced exacerbations in asthmatic children in vivo.