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Congenital Toxoplasma gondii infection can result in intracranial calcification, hydrocephalus and retinochoroiditis. Acquired infection is commonly associated

To look at the interplay between PMN and macrophages in disease progression in humans we asked whether polymorphisms at genes that regulate their infiltration..

Once upon a time it was infectious diseases like polio, measles or tuberculosis that most worried parents. With these threats now largely under control, parents face a new challenge – sky-rocketing rates of non-infectious diseases such as asthma, allergies and autism.

A researcher's work from 20 years ago has helped to crack one of biology’s biggest mysteries.

To identify genes with putative epigenetic functions, we developed an in silico pipeline to interrogate the T. gondii proteome of 8313 proteins

Overall the analyses do not suggest individual sequence variants account for differences in clinical outcome or adaptation to different hosts.

MMP1 is regulated by factors other than FLI1, and that the influence of IL-6 on MMP1 was independent of its effect on FLI1 in Leishmania braziliensis

Our results imply a role for IgG-mediated inflammation in determining delayed-type hypersensitivity associated with asymptomatic leishmaniasis

Resulting data represents the consequence of transcriptional regulation in each analyzed state of mammalian cells.

These results highlight how UNICORN can enable reliable, powerful, and convenient genetic association analyses without access to the individual-level data