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UV Irradiation of Skin Regulates a Murine Model of Multiple Sclerosis.

The prevalence of multiple sclerosis follows a latitude gradient, with increased disease at higher latitudes.

Vitamin D deficiency at melanoma diagnosis is associated with higher Breslow thickness

Background: Epidemiological evidence shows that people with thicker, or higher stage, melanomas have lower vitamin D status compared to those with thinner...

Basal cell carcinomas on sun-protected vs. sun-exposed body sites: A comparison of phenotypic and environmental risk factors

There are indications that risk factors for BCC may differ according to the anatomic site of the tumour but this is not well understood.

Comparing the effects of sun exposure and vitamin D supplementation on vitamin D insufficiency, and immune and cardio-metabolic function

Adults living in the sunny Australian climate are at high risk of skin cancer, but vitamin D deficiency (defined here as a serum 25-hydroxyvitamin D...

Nutritional approaches for the primary prevention of allergic disease: An update

The dramatic rise in early childhood allergic diseases indicates the specific vulnerability of the immune system to early life environmental changes.

Pterygium and conjunctival ultraviolet autofluorescence in young Australian adults: The Raine study

Sun exposure is associated with several ophthalmic diseases, including pterygium which may develop in adolescence.

Vitamin D in fetal development: Findings from a birth cohort study

Birth cohort studies provide an invaluable resource for studies of the influence of the fetal environment on health in later life.

Modelling vitamin D food fortification among Aboriginal and Torres Strait Islander peoples in Australia

Low vitamin D intake and prevalence of serum 25-hydroxyvitamin D concentration <50 nmol/L among Aboriginal and Torres Strait Islander peoples highlight a need for public health strategies to improve vitamin D status. Since few foods contain naturally occurring vitamin D, food fortification could be a suitable strategy. We aimed to model vitamin D food fortification scenarios among Aboriginal and Torres Strait Islander peoples.

Insights from a trial of narrowband UVB for early multiple sclerosis

There is a greater prevalence of multiple sclerosis (MS), a neurological autoimmune condition, in populations living further from the equator, hypothesised to be due to reduced sunlight exposure. There exists a proven sunlight surrogate therapy for dermatological inflammatory conditions, in the form of narrowband NB-UVB phototherapy. Yet, there is a paucity of randomized trials of the therapeutic delivery of NB-UVB beyond dermatology for conditions with a systemic inflammatory component. 

Ultraviolet radiation, vitamin D and multiple sclerosis

Recent work highlights both vitamin D and non-vitamin D effects on cellular immunity that suggests that higher levels of sun exposure and/or vitamin D status...