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Emerging Directions and New ChallengesIn this chapter we provide a brief summary of the key themes of the book, identify emerging directions and challenges in life course theory and data designs and highlight some policy challenges for researchers going forward. © 2022, The Author(s).
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Identification of distinct functional thymic programming of fetal and pediatric human γδ thymocytes via single-cell analysisDevelopmental thymic waves of innate-like and adaptive-like γδ T cells have been described, but the current understanding of γδ T cell development is mainly limited to mouse models.
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Frankenstein Cas9: engineering improved gene editing systemsThe discovery of CRISPR-Cas9 and its widespread use has revolutionised and propelled research in biological sciences.
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Healthy Environments and Lives (HEAL): Australian research network in human health and environmental changeThe HEAL Network aims to strengthen the Australian health system and community resilience to climate change, extreme events, and environmental degradation.
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Rurality as a predictor of perinatal mental health and well-being in an Australian cohortPerinatal emotional well-being is more than the presence or absence of depressive and anxiety disorders; it encompasses a wide range of factors that contribute to emotional well-being.
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The ventilatory response to hypoxia is blunted in some preterm infants during the second year of lifePreterm birth and subsequent neonatal ventilatory treatment disrupts development of the hypoxic ventilatory response (HVR). An attenuated HVR has been identified in preterm neonates, however it is unknown whether the attenuation persists into the second year of life.
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Employing cognitive interviewing to evaluate, improve and validate items for measuring the health-related quality of life of women diagnosed with ovarian cancerUse of patient-reported outcome measures in clinical settings facilitate the delivery of better health care to improve patient health outcomes.
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Remote after-care using smartphones: A feasibility study of monitoring children's pain with automated SMS messagingMonitoring children's recovery postoperatively is important for routine care, research, and quality improvement. Although telephone follow-up is common, it is also time-consuming and intrusive for families. Using SMS messaging to communicate with families regarding their child's recovery has the potential to address these concerns. While a previous survey at our institution indicated that parents were willing to communicate with the hospital by SMS, data on response rates for SMS-based postoperative data collection is limited, particularly in pediatric populations.
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‘Stranger danger’, ‘abduction risks’ and ‘fear’: Media coverage of children's independent mobility and parental attitudesThe media plays a powerful role in shaping health-related attitudes and behaviours. We investigated media reports about children's independent mobility (CIM) and associations with parental attitudes towards CIM. CIM-related media reports (newspaper, online, television) during a 3-month period were extracted from two databases.
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The role of exome sequencing in childhood interstitial or diffuse lung diseaseChildren’s interstitial and diffuse lung disease (chILD) is a complex heterogeneous group of lung disorders. Gene panel approaches have a reported diagnostic yield of ~ 12%. No data currently exist using trio exome sequencing as the standard diagnostic modality.