Search
Research
The impact of surgical cancellations on children, families, and the health system in an Australian paediatric tertiary referral hospitalReasons for elective surgery cancelations and their impact vary from one institution to another. Cancelations have emotional and financial implications for patients and their families. Our service has a particularly broad and geographically diverse patient population; hence, we sought to examine these impacts in our service.
Research
Changes in airway inflammation with pseudomonas eradication in early cystic fibrosisNeutrophil elastase is a significant risk factor for structural lung disease in cystic fibrosis, and Pseudomonas aeruginosa airway infection is linked with neutrophilic inflammation and substantial respiratory morbidity. We aimed to evaluate how neutrophil elastase (NE) activity changes after P. aeruginosa eradication and influences early disease outcomes. We assessed participants in the AREST CF cohort between 2000 and 2018 who had P. aeruginosa cultured from their routine annual bronchoalveolar lavage (BAL) fluid and who underwent eradication treatment and a post eradication BAL. Factors associated with persistent P. aeruginosa infection, persistent neutrophilic inflammation following eradication and worse structural lung disease one year post-eradication were evaluated.
Research
Application of Population-Based Linked Data to the Study of Intellectual Disability and AutismData linkage is the bringing together of specific datasets from different sources using demographic information on individuals within a population.
Research
Genetic Research and Aboriginal and Torres Strait Islander AustraliansHuman genetic research promises to deliver a range of health benefits to the population. Here we consider how the different levels of Indigenous research...
Research
The association between perinatal testosterone concentration and early vocabulary developmentPrenatal exposure to testosterone is known to affect fetal brain maturation and later neurocognitive function.
Research
Diet in the early years of life influences cognitive outcomes at 10 years: A prospective cohort studyThe aim of this study was to investigate the association between diet during the first 3 years of life and cognitive outcomes at 10 years of age.
Research
Childhood craniopharyngioma: 20-year institutional experience in Western AustraliaAlthough neurocognitive, psychological and behavioural problems were noted for some patients during medical review, only 20% of patients were formally assessed.
Research
Immune modulation by UV: Role of vitamin DIn this chapter, evidence for and evidence against the involvement of vitamin D in the immunoregulatory properties of UV radiation is presented.
Research
Neutrophil Extracellular Traps and Bacterial Biofilms in Middle Ear Effusion of Children with Recurrent Acute Otitis MediaBacteria persist within biofilms on the middle ear mucosa of children with recurrent and chronic otitis media however the mechanisms by which these...
Research
Consensus statement for inert gas washout measurement using multiple- and single- breath testsInert gas washout tests, performed using the single- or multiple-breath washout technique, were first described over 60 years ago.