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Research

Factors influencing adult and adolescent completion of treatment for late syphilis: a mixed methods systematic review

To identify factors influencing the completion of a three-dose course of weekly intramuscular benzathine penicillin G injections by adults and adolescents with syphilis of unknown duration or late syphilis.

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E-cigarette use among gender and sexuality diverse (LGBTQA+) adolescents in Australia: The case for LGBTQA+ affirmative harm reduction

This study aimed to provide a first-ever comprehensive epidemiology of vaping behaviours among Australian gender and sexuality diverse (LGBTQA+) youth.

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What helps cardiac patients exercise after treatment, and when? Understanding physical activity and exercise participation following exercise-based cardiac rehabilitation

Despite evidence suggesting regular exercise (i.e. structured, repetitive and purposeful physical activity) attenuates cardiac patients’ decline in health, our understanding of factors affecting long-term exercise participation among this patient cohort is limited. This problem is pertinent, given that less than half of cardiac patients adhere to exercise following discharge from formal exercise-based rehabilitation programmes. In this study, we explored factors influencing exercise participation after an outpatient cardiac rehabilitation programme. 

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What influences the implementation of health checks in the prevention and early detection of chronic diseases among Aboriginal and Torres Strait Islander people in Australian health care

This review aims to systematically identify contextual and mechanistic factors that contribute to the success or failure of implementing effective HCs in the prevention and early detection of chronic diseases among Aboriginal and Torres Strait Islander people in Australian primary health care (PHC).

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Mental health assessment of transgender youth - Should standardised psychological measures be scored by norms of birth-registered sex?

Standardised psychometric measures are used in mental health care and research settings to identify risk, assist diagnosis, and assess symptom severity. Standardised scoring of these measures involves transforming respondents' raw scores using binary sex norms. However, scoring manuals offer no guidance as to appropriate scoring methods for trans and non-binary respondents.

Research

Normative values for lung, bronchial sizes, and bronchus-artery ratios in chest CT scans: from infancy into young adulthood

To estimate the developmental trends of quantitative parameters obtained from chest computed tomography (CT) and to provide normative values on dimensions of bronchi and arteries, as well as bronchus-artery (BA) ratios from preschool age to young adulthood.

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Awake Supraglottic Airway Placement in Pediatric Patients for Airway Obstruction or Difficult Intubation: Insights From an International Airway Registry (PeDI)

Small case series have described awake supraglottic airway placement in infants with significant airway obstruction and difficult intubations. We conducted this study to determine outcomes when supraglottic airways were placed in awake children enrolled in the international Pediatric Difficult Intubation Registry including success of ventilation, success of tracheal intubation, and complications.

Research

Pregnancy with multiple high-risk factors: a systematic review and meta-analysis

A wide spectrum of high-risk factors in pregnancy can lead to adverse pregnancy outcomes or short- or long-term health effects. Despite this, there has been no synthesis of findings on the measurement, potential causes, and health outcomes of multiple high-risk factors in pregnancy. We aimed to address this gap by summarising the existing research on this topic.

Research

Malaria in Nepal: A Spatiotemporal Study of the Disease Distribution and Challenges on the Path to Elimination

Malaria incidence (MI) has significantly declined in Nepal, and this study aimed to investigate the spatiotemporal distribution and drivers of MI at the ward level. Data for malaria cases were obtained from the National Surveillance System from 2013 to 2021. Data for covariates, including annual mean temperature, annual mean precipitation, and distance to the nearest city, were obtained from publicly available sources. A Bayesian spatial model was used to identify factors associated with the spatial distribution of MI.

Research

The Vsr-like protein FASTKD4 regulates the stability and polyadenylation of the MT-ND3 mRNA

Expression of the compact mitochondrial genome is regulated by nuclear encoded, mitochondrially localized RNA-binding proteins (RBPs). RBPs regulate the lifecycles of mitochondrial RNAs from transcription to degradation by mediating RNA processing, maturation, stability and translation. The Fas-activated serine/threonine kinase (FASTK) family of RBPs has been shown to regulate and fine-tune discrete aspects of mitochondrial gene expression.