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Review of Aboriginal child health services in remote Western Australia identifies challenges and informs solutionWe aimed to identify and map child health services in the very remote Fitzroy Valley, West Kimberley, and document barriers to effective service delivery
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Associations Between Sun Exposure and Adiposity Were Not Observed in Breast and Prostate Cancer Patients in a Cross-sectional AnalysisThere were no statistically significant associations between time spent outdoors and adiposity
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Empathy for others’ pain is disrupted at the neurophysiological level in schizophreniaThese data suggest that empathy for pain is disrupted at the neurophysiological level in schizophrenia
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The Nguudu Barndimanmanha Project-Improving Social and Emotional Wellbeing in Aboriginal Youth Through Equine Assisted LearningWe observed improvements in self-regulation, self-awareness, and socialization skills, evident from the photography recording and the questionnaire data
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The reproduction of educational inequalities – do parenting and child behavioural problems matter?Parenting styles and child behavioural problems may be potential pathways that underpin the influence of parental SES on children’s school achievement
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Healthy population ageing depends on investment in early childhood learning and developmentInterventions in the early years provide a sustainable solution by generating long-term labour productivity and social welfare benefits
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Transplacental Innate Immune Training via Maternal Microbial Exposure: Role of XBP1-ERN1 Axis in Dendritic Cell Precursor ProgrammingWe recently reported that offspring of mice treated during pregnancy with the microbial-derived immunomodulator OM-85 manifest striking resistance to allergic airways inflammation, and localized the potential treatment target to fetal conventional dendritic cell (cDC) progenitors. Here, we profile maternal OM-85 treatment-associated transcriptomic signatures in fetal bone marrow, and identify a series of immunometabolic pathways which provide essential metabolites for accelerated myelopoiesis.
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Lower Cord Blood IL-17 and IL-25, but Not Other Epithelial Cell-Derived Cytokines Are Associated with Atopic Dermatitis in InfancyThere is a growing need for early biomarkers that may predict the development of atopic dermatitis (AD). As alterations in skin barrier may be a primary event in disease pathogenesis, epithelial cell (EC) cytokines expression patterns may be a potential biomarker in early life to target allergy preventive strategies towards "at-risk" infants. The aim of this longitudinal investigation was to examine from birth over the course of infancy levels of the EC cytokines: thymic stromal lymphopoietin (TSLP), interleukin (IL)-33, IL-25, and IL-17 in infants at high-risk of AD due to maternal atopy.
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Genetics, Transcriptomics and Meta-Taxonomics in Visceral LeishmaniasisVisceral leishmaniasis (VL) caused by parasites of the Leishmania donovani complex can be fatal in susceptible individuals. Understanding the interactions between host and pathogen is one way to obtain leads to develop better drugs and for vaccine development. In recent years multiple omics-based approaches have assisted researchers to gain a more global picture of this interaction in leishmaniasis. Here we review results from studies using three omics-based approaches to study VL caused by L. donovani in India.
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Do sex hormones at birth predict later-life economic preferences? Evidence from a pregnancy birth cohort study: Hormones at birth and preferencesEconomic preferences may be shaped by exposure to sex hormones around birth. Prior studies of economic preferences and numerous other phenotypic characteristics use digit ratios (2D : 4D), a purported proxy for prenatal testosterone exposure, whose validity has recently been questioned. We use direct measures of neonatal sex hormones (testosterone and oestrogen), measured from umbilical cord blood (n = 200) to investigate their association with later-life economic preferences (risk preferences, competitiveness, time preferences and social preferences) in an Australian cohort (Raine Study Gen2).